The promiscuous IL-2/IL-15 receptor: a target for immunotherapy of HTLV-I-associated disorders

Article Abstract:

The use of humanized monoclonal antibodies to the Tac peptide of the interleukin-2 receptor (IL-2R) may be effective in treating adult T-cell leukemia (ATL). ATL is caused by the human T-cell lymphotropic virus type I (HTLV-I). When T cells become infected with HTLV-I, they express IL-2R. However, normal T cells do not express IL-2R. Nine of 18 ATL patients who received humanized monoclonal antibodies against the Tac peptide of IL-2R went into partial or complete remission. In some cases, the antibody contained a radioactive substance to destroy the cancerous T cells.

Care and treatment, Evaluation, Interleukin-2, Immunotherapy, Drug receptors, Adult T-cell leukemia-lymphoma

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Neutralizing antibodies against HIV determined by amplification of viral long terminal repeat sequences from cells infected in vitro by nonneutralized virions

Article Abstract:

Researchers report the development of a technique to measure the immune system response to antibodies against HIV. Virus neutralizing antibodies have prevented infection after exposure to HIV-like viruses in chimpanzees and mice. Patients who remain healthy despite HIV infection may have high levels of viral neutralizing antibodies in their blood. A molecular assay using a polymerase chain reaction (PCR) technique may be used to detect HIV neutralization by antibodies.

Research, Methods, Measurement, Polymerase chain reaction, Monoclonal antibodies, AIDS vaccines, HIV antibodies

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