Constitutive release of metalloproteinase-9 (92-kd type IV collagenase) by Kaposi's sarcoma cells

Article Abstract:

Kaposi's sarcoma (KS) cells release significant amounts of metalloproteinase-9, a type of collagen-dissolving enzyme which may contribute to new blood vessel growth and cellular invasion necessary to sustain the tumor. KS in invasive cancer which can develop in AIDS patients. Researchers compared collagenase release in KS cells and human umbilical vein cells. While human umbilical cells showed only weak collagenase activity, KS cells released substantial amounts of the enzymes. Exposure to chemotherapy agents suppressed metalloproteinase release in KS cells.

Physiological aspects, Metalloenzymes, Kaposi's sarcoma, Collagenases

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Prevention of opportunistic infections in the era of improved antiretroviral therapy

Article Abstract:

More effective AIDS drugs such as protease inhibitors may raise CD4 cell counts high enough so patients may discontinue using drugs to prevent opportunistic infections. These infections usually only occur in people with severely suppressed immune systems.

Prevention, Opportunistic infections

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