CD8+ lymphocyte responses to antiretroviral therapy of HIV infection

Article Abstract:

Protease inhibitors appear to increase blood levels of CD8 T cells but it is not clear whether this will prevent the progression of HIV infection. Researchers reviewed 7 clinical trials of zidovudine alone or in combination with didanosine or zalcitabine as well as 2 clinical trials of the protease inhibitor ritonavir. Only ritonavir significantly increased CD8 T cell levels. CD8 T cells often rise following HIV infection and drop as the infection progresses to AIDS. This indicates that these immune cells are capable of suppressing the virus.

Measurement, Protease inhibitors, CD8 lymphocytes

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The role of hydroxyurea in enhancing the virologic control achieved through structured treatment interruption in primary HIV infection: Final results from a randomized clinical trial (pulse)

Article Abstract:

Structured treatment interruptions (STIs) are posulated to improve virologic control in primary HIV infection (PHI) by simulating HIV-specific T-lymphocyte immunity. It is concluded that hydroxyurea is found to be beneficial when used in association with STIs in patients during PHI.

Prevention, Complications and side effects, Dosage and administration, Hydroxyurea, Clinical report

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Buffalo hump seen in HIV-associated lipodystrophy is associated with hyperinsulinemia but not dyslipidemia

Article Abstract:

A study was conducted to identify risk factors for a buffalo hump (BH) in HIV-infected adults in cross-sectional analyses of 2 HIV-infected ambulatory populations. Patients with a BH had a high prevalence of other features of HIVLD, similar to lipodystrophic patients without a BH.

United States, Health aspects, HIV patients, Metabolic diseases, Lipodystrophy

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