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Cancer genes and the pathways they control

Article Abstract:

Cancer-gene mutations, which enhance net cell growth, are studied. It is found that eradicating billions of cancer cells with multiple genetic abnormalities is a daunting task and the number of pathways that could be targeted by new generation of drugs is limited, knowledge of the genes altered in cancer will provide the basis for new generations of diagnostic tests, prevention and early detection are the most feasible means to reduce cancer deaths.

Author: Kinzler, Kenneth W., Vogelstein, Bert
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
Cancer cells

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Combinatorial chemoprevention of intestinal neoplasia

Article Abstract:

Research reveals that a combination of a non-steroidal anti-inflammatory drug sulindac and a newly developed epidermal growth factor inhibitor EKI-569 is a good strategy for the chemoprevention of human colonic neoplasia. Data show that about 50% of the treated mice stayed free of polyps whereas 100% of untreated developed approximately 20 polyps.

Author: Kinzler, Kenneth W., Vogelstein, Bert, Torrance, Christopher J., Jackson, Peta E., Montgomery, Elizabeth, Wissner, Allan, Nunes, Maria, Frost, Philip, Discafani, Carolyn M.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
United States, Statistical Data Included, Testing, Drug therapy, Growth, Antineoplastic agents, Tumors, Chemotherapy, Combination, Combination chemotherapy, Sulindac, Gastrointestinal cancer, Digestive system cancer

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Cancer genes and the pathways they control

Article Abstract:

The features of many important genes responsible for the genesis of various cancers, and their mutations precisely identified, are presented. The progresses in the area of cancer research and the possibilities for future investigations are discussed.

Author: Kinzler, Kenneth W., Vogelstein, Bert
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Cancer & Cell R&D, Cancer research, Oncology, Experimental

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Subjects list: Research, Physiological aspects, Gene mutations, Gene mutation, Oncogenes
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