Closer to a Cure for the Common Cold?

Article Abstract:

More research is needed before the drug tremacamra can be used to prevent or treat colds. Tremacamra is a form of the receptor for the intercellular adhesion molecule 1. Most colds are caused by rhinoviruses, and they use this cell receptor to enter the cell. Giving people tremacamra would block the virus and keep it from entering the cell. A 1999 study found that tremacamra did not prevent colds but it reduced symptoms. It was no more effective when given before the volunteers were exposed to rhinoviruses as it was when given after exposure. However, not all colds are caused by rhinoviruses.

Care and treatment, Editorial, Cold (Disease), Common cold

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Antiretroviral treatment in pediatric HIV infection in the United States: From clinical trials to clinical practice

Article Abstract:

The changes in the treatment of pediatric HIV infection in the US from 1987-2003 are described, an assessment of concordance of initial regimens with US pediatric guidelines is presented and predictors of the first regimen switch are identified. It is concluded that there was a short lag between the identification of novel antiretroviral therapy (ART) and its adoption in the pediatric community.

United States, Usage, Drug therapy, AIDS (Disease) in children, Pediatric AIDS (Disease), Antiretroviral agents

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Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1

Article Abstract:

A combination of AIDS drugs that includes a protease inhibitor has caused annual mortality rates in HIV-infected children and teenagers to drop from 5.3% in 1996 to 0.7% in 1999. Only 7% of HIV-infected children and teenagers received combination therapy in 1996, compared to 73% in 1999.

Statistical Data Included, Patient outcomes, Mortality, HIV infection in children, Protease inhibitors, Pediatric HIV infections

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