Daily versus thrice-weekly interferon alfa-2b plus ribavirin for the treatment of chronic hepatitis C in HIV-infected persons: a multicenter randomized controlled trial

Article Abstract:

A randomized, controlled, open-label, multicenter trial was conducted to establish the safety, efficacy of interferon alfa (IFN) alfa-2b 3 mIU daily plus ribavirin (RBV) compared with IFN alfa-2b 3mIU thrice weekly plus RBV in the treatment of chronic hepatitis C virus (HCV) in HIV-infected adults. Study revealed that the continuous exposure to IFN-daily injections is more effective than intermittent exposure via thrice-weekly injections.

HIV infection, HIV infections, Interferon alpha

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Diagnosis of heptic fibrosis and cirrhosis by transient elastography in HIV/hepatitis C virus-coinfected patients

Article Abstract:

An approximate of 72 consecutive HIV patients with chronic hepatitis C who had a simultaneous liver biopsy and liver stiffness measurement by transient elastogarphy for the assessment of the liver fibrosis, is studied. Liver stiffness measurement is a promising non-invasive method for the assessment of fibrosis in HIV-infected patients with chronic HCV infection.

Diagnosis, Lung diseases

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Baseline serum hepatitis C virus (HCV) RNA level and response at week 4 are the best predictors of relapse after treatment with pegylated interferon plus Ribavirin in HIV/HCV-coinfected patients

Article Abstract:

The present study aims at finding the main predictors of relapse after treatment with pegylated interferon (peg-IFN) plus Ribavirin (RBV) in HIV/HCV-coinfected patients. High baseline serum hepatitis C virus (HCV) RNA level and lack of undetectable viremia at week four are found to be significant indicators of relapse.

Patient outcomes, Diseases, Drug therapy, Recurrence (Disease), Clinical report, Peginterferon alfa-2a

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