Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4+ T cells

Article Abstract:

Research demonstrates that dendritic cells with CD40 ligand when primed with heat-killed Pseudomonas, express B cells against Pseudomonas in the absence of CD4+ T cells. Data show that the cells exhibit pseudomonas-specific humoral immune response in wild-type mice lacking CD4 but not in B-cell lacking mice.

Analysis, Physiological aspects, Pseudomonas, Immunity, Immunity (Physiology), T cells, Immune response, Antigen presenting cells, CD4 lymphocytes, Immune response regulation

---

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

Article Abstract:

Research presented concerns the association between bone marrow-derived precursor cells and tumor angiogenesis. Findings suggest that recruitment of vascular endothelial growth factor bone marrow-derived cells promotes tumor angiogenesis, thus blocking these cells may have implications for halting tumor growth.

Statistical Data Included, Growth, Neovascularization, B cells, Vascular endothelial growth factor, Tumors

---

Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency

Article Abstract:

A study was conducted to demonstrate the use of trans-splicing to correct the CD40L mutation while preserving the natural regulation and cell specificity of CD40L expression in a mouse CD40L-knockout model. The result confirms the use of CD40L trans-splicing to correct hyper-IgM (HIGM1), leading to functional correction of the genetic defect without the adverse consequences of unregulated expression of the CD40L gene.

Science & research, Gene mutations, Gene mutation, Gene expression

Similar abstracts:

• Abstracts: Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis
• Abstracts: Predictors of failed attempted abortion with the antiprogestin mifepristone (RU 486). Medical abortion: public health and private lives
• Abstracts: Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic inflammatory process. A dual function for CD40 agonists
• Abstracts: Dexamethasone induction of hypertention and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
• Abstracts: Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.