Efavirenz versus nevirapine in current clinical practice: A prospective, open-label observational study

Article Abstract:

An open-label, observational, prospective 18-month survey is conducted to compare the efficacy and tolerability of efavirenz and nevirapine, the two-nonnucleoside reverse transcriptase inhibitors (NNRTIs) in all-possible indication available in current clinical practice. A limited virologic and immunologic advantage of efavirenz was observed in the first 12-month assessment of antiretroviral-naive patients, whereas all other examined situations did not disclose relevant efficacy differences.

United States

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Effectiveness of generic fixed-dose combinations of highly active antiretroviral therapy for treatment of HIV infection in India

Article Abstract:

The clinical and immunologic effectiveness and acute toxicity to nevirapine (NVP)-based fixed-dose combinations (FDCs) in antiretroviral-native HIV-1 infected patients in India is studied. Fixed-dose formulations of NVP-based combination therapy are safe and produced durable clinical and immunologic benefit.

India, Analysis, Complications and side effects, HIV infection, Drug therapy, HIV infections, Highly active antiretroviral therapy

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Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism

Article Abstract:

The impact of the CYP2B6-G516T gene polymorphism on plasma concentrations of efavirenz (EFV) in HIV-1-infected children is investigated. It is found that CYP2B6-G516T polymorphisms significantly affect the median oral clearance rate of EFV in children.

Science & research, Research, Genetic polymorphisms, Clinical report, Efavirenz

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