Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury

Article Abstract:

Researchers have shown that stem cells or precursor cells have contributed to the replacement of adult mammalian cardiomyocytes after injury, but does not contribute to cardiomyocyte renewal during normal aging. The results have provided indirect evidence for the involvement of progenitor cells in the increase in [GFP.sup.-] cells and an immature population of cardiomyocytes might be responsible for the formation of new cardiomyocytes.

Stem cells, Stem cell transplantation, Clinical report, Cardiomyoplasty

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The role of autophagy in cardiomyocytes in the basal state and in response to homodynamic stress

Article Abstract:

A study reported to show that the cardiac-specific loss of autophagy causes cardiomyopathy in mice, is conducted. The results indicate that constiturtive autophagy in the heart under baseline conditions is a homeostatic mechanism for maintaining cardiomyocyte that upregulation of autophagy in failing hearts is an adaptive response for protecting cells from hemodynamic stress.

Analysis, Hemodynamics, Homeostasis

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Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

Article Abstract:

The c-Jun N-terminal kinase 1 (JNK) pathway is known to be activated in several tissues in the diabetic state, and is possibly involved in the development of insulin resistance. The experiment data indicate that the JNK pathway is critically involved in diabetes and the cell-permeable JNK-inhibitory peptide may prove a new therapeutic agent for diabetes.

United States, Health aspects, Care and treatment, Diabetes, Diabetes mellitus, Peptides, Insulin resistance

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