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Human susceptibility and resistance to Norwalk virus infection

Article Abstract:

The protective immunity to Norwalk virus infection in humans is multifactorial. Research reveals that 29% of the study population is homozygous recessive for the secretor phenotype gene FUT2 and does not express the H type-1 oligosaccharide ligand involved in the virus binding. Furthermore, a portion of the susceptible population exhibit FUT gene and hence show resistance to infection, indicating to the existence of a memory immune response.

Author: Jiang, Xi, Lindesmith, Lisa, Moe, Christine, Marionneau, Severine, Ruvoen, Nathalie, Lindblad, Lauren, Stewart, Paul, LePendu, Jacques, Baric, Ralph
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Analysis, Infection, Population genetics, Disease susceptibility, Norwalk virus

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Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

Article Abstract:

Research describes modification of the live tuberculosis BCG vaccine by the introduction of region of deletion-1 locus into the Mycobacterium tuberculosis. Results indicate that introduction of the complete locus, containing a minimum of 11 genes, leads to the full secretion of the antigens and immune response.

Author: Cole, Stewart T., Williams, Ann, Pym, Alexander S., Brodin, Priscille, Majlessi, Laleh, Brosch, Roland, Demangel, Caroline, Griffiths, Karen E., Marchal, Gilles, LeClerc, Claude
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
United Kingdom, Innovations, Evaluation, Physiological aspects, Design and construction, Immune response, Recombinant molecules, BCG vaccines, BCG, Tuberculosis vaccines

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A low-carb diet for a high-octane pathogen

Article Abstract:

A brief description on the role of one metabolic pathway required for Mycobacterium tuberculosis to survive on host-derived lipids is presented. It might guide future efforts to develop new intervention strategies based on an understanding of the in vivo physiology of the bacterium.

Author: Boshoff, H.I., Barry, C.E., III
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Lipids, Pathogenic microorganisms

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Subjects list: Research, United States, France, Genetic aspects, Mycobacterium tuberculosis
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