Mibefradil - a new calcium channel blocker

Article Abstract:

The Food and Drug Administration has approved the first T-type calcium channel blocker, mibefradil dihydrochloride, for use in treating high blood pressure and stable angina. T-type refers to its ability to act on transient T-type calcium channels as well as the long-acting L-type channels all other calcium channel blockers affect. Mibefradil allows dilation of the blood vessels without decreasing the ability of the muscles of the heart to contract. It is not known if the effect on T-channels provides any additional benefit. The drug is marketed by Roche under the name Posicor.

Licensing agreements, United States. Food and Drug Administration, Calcium channel blockers, Posicor (Medication)

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Eplerenone (Inspra)

Article Abstract:

Eplerenone is an aldosterone receptor blocker is used for the treatment of hypertension and possibly for heart failure as well. Results indicate that it is modestly effective for hypertension and decreases mortality from congestive heart failure.

Cooking, Physiological aspects, Aldosterone assay, Aldosterone, Cookery for hypertensives

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Nesiritide for decompensated congestive heart failure

Article Abstract:

The FDA has approved Natrecor for the treatment of severe congestive heart failure. Produced by Scios, Inc., the drug is a recombinant form of human B-type natriuretic peptide. It makes blood vessels dilate, or become larger.

Pharmaceutical industry, Scios Inc., NOVX, Natrecor (Medication)

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