Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling

Article Abstract:

The contribution of exaggerated Stat3 activation to the phenotype of gp130 (super Y757F/Y757F) mice is genetically assessed on the disruption of the negative feedback mechanism on gp 130-dependent Stat signaling by a knock-in mutation. Results indicate an increase in lifespan, prevention of splenomegaly, normalized exaggerated hepatic acute-phase response and lymphocyte trafficking and suppression of the growth of spontaneously arising gastric adenomas in young mice.

Science & research, Observations, Mice, mutant strains, Mutant mice, Phenotype, Phenotypes, Adenocarcinoma

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Genetic model of selective COX2 inhibition reveals novel heterodimer signaling

Article Abstract:

A new genetic mouse model of selective cyclooxygenase-2 (COX2) inhibition using a gene-targeted point mutation, results in an Y385F substitution. Structural modeling and biochemical assays showed the ability of prostaglandin H synthase-1 (PGHS1) and PGHS2 to heterodimerize and form prostaglandins.

United Kingdom, COX-2 inhibitors, Prostaglandins

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Characterization of a newly discovered T-cell receptor beta-chain heterodimer expressed on a CD8+ bone marrow subpopulation that promotes allogeneic stem cell engraftment

Article Abstract:

Research reveals a CD3epsilon-associated complex of CD8+ cell exhibiting T-cell receptor beta-chain disulfide-linked to a 33-kilodalton glycoprotein called beta-FCp33. Data show that expression of beta-FCp33 complex enhances allogeneic stem cell enlargement mediated by the CD8+ cells.

Usage, Flow cytometry, Immunology, T cell antigen receptors, T cells, Bone marrow cells, CD8 lymphocytes

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