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Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA

Article Abstract:

A DNA vaccine against human papillomavirus (HPV) with the experimental name ZYC101 may be effective in curing cervical intraepithelial neoplasia (CIN), according to a study of 15 women with CIN grade 2 or 3 and infection with HPV 16. Eleven of the women developed an immune response to HPV and five were cured of the disease. CIN is considered a precancerous condition that can progress to cervical cancer.

Author: Crowley-Nowick, Peggy A., Gold, Michael A., Muderspach, Laila I., Crum, Christopher P., Politch, Joseph A., Urban, Robert G., Sheets, Ellen E., Hedley, Mary Lynne, Cole, Geoffrey A.
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2003
Evaluation, DNA vaccines

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A cost-effectiveness analysis of management strategies for cervical intraepithelial neoplasia grades 2 and 3

Article Abstract:

Cryotherapy may be the most cost-effective treatment for precancerous cervical disease, according to a hypothetical group of 100,000 women. Loop electrosurgical excision procedure (LEEP) is more effective than cryotherapy, but is also more expensive. Hysterectomy is the most effective treatment but also the most expensive treatment.

Author: Kleinberg, Marc J., Straughn, J. Michael, Stringer, Jeffery S.A., Partridge, Edward E.
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2003
Medical care, Cost of, Health care costs, Cost benefit analysis

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The borderline or weakly positive hybrid capture II HPV test: A statistical and comparative (PCR) analysis

Article Abstract:

Recent studies have hypothesized that laboratory contamination may influence interpretation of hybrid capture II (HCII) human papillomavirus (HPV) detection assay values. Cross-well contamination of samples occurs during processing, and may influence interpretation of some borderline positives.

Author: Crum, Christopher P., Federschneider, Jerome M., Yuan, Liping, Brodsky, Joshua, Breslin, Gillian, Betensky, Rebecca A.
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2004
Causes of, Risk factors, Influence, Laboratory infections

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Subjects list: Care and treatment, Papillomavirus infections, Cervix dysplasia
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