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Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-89) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand

Article Abstract:

Results of a trial vaccine efficacy experiment are presented. The myelin basic protein peptide is the antigen involved in the pathogenesis of multiple sclerosis and an altered peptide of this antigen elicited adverse immune response in two of the three patients who showed encephalitogenic potential of the myelin peptide.

Author: Bielekova, Bibiana, Goodwin, Bonnie, Richert, Nancy, Cortese, Irene, Kondo, Takayuki, Apshar, Ghazaleh, Gran, Bruno, Eaton, Joan, Antel, Jack, Frank, Joseph A., McFarland, Henry F., Martin, Roland
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Encephalitis

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Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

Article Abstract:

Results of a placebo-controlled phase II clinical trial, involving an altered peptide ligand of the myelin basic protein, are presented. Data indicate that 9% of the treated developed hypersensitivity, and a reduction in the volume and number of lesions at a dose of 5 milligram.

Author: Steinman, Lawrence, Antel, Jack, Kappos, Ludwig, Comi, Giancarlo, Panitch, Hillel, Oger, Joel, Conlon, Paul
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Italy, Switzerland, Allergy, T cells

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Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease

Article Abstract:

Researchers have developed a technique that can identify bacterial T-cell epitopes as well as autoantigens that mimic bacterial antigens. This technique will be useful in research on autoimmune diseases, which are thought to be caused by autoantigens that mimic microbial antigens.

Author: Bielekova, Bibiana, Cortese, Irene, Kondo, Takayuki, Gran, Bruno, McFarland, Henry F., Martin, Roland, Straus, Stephen E., Simon, Richard (French biblical critic), Pinilla, Clemencia, Marques, Adriana, Hemmer, Bernhard, Zhao, Yingdong, Pascal, Jeannick, Tzou, Abraham, Houghten, Richard
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Research, Lyme disease, Identification and classification, Autoantigens, Antigenic determinants

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Subjects list: Statistical Data Included, United States, Analysis, Canada, Evaluation, Physiological aspects, Peptides, Multiple sclerosis, Myelin proteins
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