Interleukin-7 receptor expression on CD8(super.+) T cells is reduced in HIV infection and partially restored with effective antiretroviral therapy

Article Abstract:

Interleukin-7 (IL-7) receptor expression on CD8(super.+) T cells has been found to be lowered in HIV infection and partially restored with effective antiretroviral therapy (ART). IL-7 enhances CD8 T-cell proliferation and cytolytic activity. The expression of its receptor, CD127 (IL-7R alpha), may thus be important in HIV immunopathogenesis.

Canada, Interleukins, T cells

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Nonnucleoside reverse transcriptase inhibitor resistance among antiretroviral-naive HIV-positive pregnant women

Article Abstract:

Research has been conducted on resistance in antriretroviral-naive pregnant women in St. Louis, Missouri. The hypothesis that resistance testing in antiretroviral-naive HIV-positive pregnant women has identified resistant mutations which would modify the therapy choice has been verified, and the details are reported.

United States, Biological Product (except Diagnostic) Manufacturing, Nucleic Acid Derivatives, Usage, Gene mutations, Gene mutation, Pregnant women, Nucleosides, Chemical inhibitors

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Survival benefit from non-highly active antiretroviral therapy in a resorce-constrained setting

Article Abstract:

Research has been conducted on mortality rates in HIV-1-infected patients in Thailand. This study has been carried out in investigating the effect of antiretroviral drug therapy o n mortality, and the results demonstrate that suboptimum antiretroviral drug regimens including dual therapy have survival benefit.

Japan, Thailand, Mortality, Causes of, Demographic aspects, Drug therapy

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