Intra-articular hyaluronan treatment of osteoarthritis

Article Abstract:

Hyaluronan injections into painful osteoarthritic joints may reduce pain and improve joint function, but clinical research studies have produced equivocal results. Hyaluronan is a high-molecular-weight polysaccharide that lubricates the joint, reduces inflammation, and induces other therapeutic changes when injected into the synovial fluid of joints. Only a few of the many research studies of hyaluronan injection have properly controlled for placebo effects and research biases. Nevertheless, hyaluronan may be beneficial in some patients for whom surgery or corticosteroid injection is not possible or is ineffective.

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Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomised, double blind, placebo controlled multicentre trial

Article Abstract:

Older patients with more advanced knee osteoarthritis (OA) seem to benefit the most from hyaluronan injections into the knee joint. Doctors gave five weekly injections of either hyaluronan or placebo into the knee joints of 240 patients with knee OA. Overall, both placebo and hyaluronan treatment groups showed improvement in pain and function scores. The only subgroup of patients that showed more improvement with hyaluronan rather than placebo injections was those over 60 years with advanced disease. There were no serious side effects reported with either treatment.

Evaluation, Injections, Intra-arterial, Intra-arterial injections

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Randomised controlled trial of intra-articular corticosteroid injection of the carpometacarpal joint of the thumb in osteoarthritis

Article Abstract:

Randomised controlled trial of intra-articular corticosteroid injection of the carpometacarpal joint of the thumb in

Science & research, Research, Usage, Clinical trials, Diseases, Corticosteroids, Thumb, Corticosteroid drugs

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