Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine

Article Abstract:

Zidovudine does not appear to cause cancer in infants exposed during and after pregnancy but long-term follow-up studies are needed to confirm this. Pregnant HIV-infected women who take zidovudine can dramatically lower the risk of passing the virus on to their baby. Researchers analyzed the rate of cancer in 727 children known to have been exposed to zidovudine during pregnancy or after birth. None of the children had developed cancer after an average follow-up of three years. Mice given zidovudine developed a precursor of vaginal cancer, but the doses were much higher than humans take.

Complications and side effects, Risk factors, Cancer, Zidovudine

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Maternal and perinatal factors related to maternal-infant transmission of HIV-1 in the P(super)2C(super)2 HIV Study: the role of EBV shedding. (Epstein-Barr virus)

Article Abstract:

Several maternal characteristics appear to increase the chance that an HIV-infected pregnant woman will transmit HIV to her baby. Researchers analyzed the characteristics of 508 HIV-infected pregnant women, 18% of whom had an HIV-infected baby. Low CD4 counts were associated with HIV transmission, as was premature rupture of membranes and bleeding. Like many adults, many of the women had been exposed to the Epstein-Barr virus (EBV) and those with active EBV infection were more likely to transmit HIV to their baby.

Health aspects, Research, Maternal-fetal exchange, Epstein-Barr virus diseases

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Elevated CD8+DR+ lymphocytes in HIV-exposed infants with early positive HIV cultures: a possible early marker of intrauterine transmission

Article Abstract:

An elevation in the percentage of CD4+ and HLA-DR+ lymphocytes in the blood of newborn infants of HIV-infected mothers indicates those who may have been infected with HIV in the uterus rather than during delivery. Infants who tested positive for HIV during the first seven days of life had much higher levels of CD4+DR+ lymphocytes than infants who tested positive during the first six months of life.

United States, Statistical Data Included, Physiological aspects, CD8 lymphocytes, Serodiagnosis, Serologic tests

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