Limited evolution of HIV antiretroviral drug resistance-associated mutations during the performance of drug resistanse testing
Article Abstract:
Research has been conducted on HIV reverse transcriptase evolution and protease-associated antiretroviral drug resistance mutations during genotypic drug resistant testing. Results demonstrate that there is association between duration of previous protease-associated antiretroviral therapy and gain of reverse transcriptase-associated resistance mutations, and that the patients should continue current therapy until test results are available.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2003
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Results of a phase 2 clinical trial at 48 weeks (AI424-007): a dose-ranging, safety, and efficacy comparative trial of atazanavir at three doses in combination with didanosine and stavudine in antiretroviral-naive subjects
Article Abstract:
Research has been conducted on protease inhibitor atazanavir. The dose levels of this medication have been compared with those of nelfinavir as a monotherapy and in combination with didanosine and stavudine, and the results of this clinical trial carried out to compare safety, tolerability and antiretroviral efficacy of these three doses are reported.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2003
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A cross-sectional survey of HIV genotype mutations conferring resistance to all nonnucleoside reverse transcriptase inhibitors and related features, at the time of failure of antiretroviral therapy in the real world
Article Abstract:
The author discusses resistance to nonnucleoside reverse transcriptase inhibitor resistance testing. Results demonstrate that resistance testing favourably drives the switch of highly active antiretroviral therapy regiments, especially during virologic failure.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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