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Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract

Article Abstract:

A study investigates whether histologic differentiation of the distinct subtypes of epithelial ovarian cancers (EOCs) involves aberrant expression of Abd-B-like HOX genes. It was found that HOX genes, which normally regulate mullerian duct differentiation, are not expressed in normal ovarian surface epithelium (OSE), but are expressed in different EOC subtypes according to the pattern of mullerian-like differentiation of these cancers.

Author: Jinsong Liu, Wenjun Cheng, Yoshida, Hiroyuki, Rosen, Daniel, Naora, Honami
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Genetic aspects, Genetic research

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GTP cyclohydrolase and tetrahydrobioterin regulate pain sensitivity and persistence

Article Abstract:

GTP-cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis is a key modulator of peripheral neuropathic and inflammatory pain. It is concluded that BH4 is an intrinsic regulator of pain sensitivity and chronicity, and the GTP cyclohydrolase haplotype is a marker for these traits.

Author: Schmidt, Helmut, Allchorne, Andrew, Woolf, Clifford J., Goldman, David, Max, Mitchell B., Atlas, Steven J., Tegeder, Irmgard, Costigan, Michael, Griffin, Robert S., Abele, Andrea, Belfer, Inna, Ehnert, Corina, Nejim, Jemiel, Marian, Claudiu, Scholz, Joachim, Tianxia Wu, Diatchenko, Luda, Binshtok, Alexander M., Adolph, Jan, Sama, Swetha, Carlezon, William A., Parsegian, Aram, Lotsch, Jorn, Fillingim, Roger B., Maixner, William, Geisslinger, Gerd
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
Haplotypes

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The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers

Article Abstract:

The role of RAB25 in the aggressiveness of ovarian and breast cancers is evaluated by altering RAB25 levels. The study implicates RAB25 in the aggressiveness of ovarian and breast carcinomas suggesting that RAB25 can be used to predict patient outcome and may provide a novel therapeutic target. .

Author: Smith-McCune, Karen, Kwai Wa Cheng, Lahad, John P., Wen-lin Kuo, Lapuk, Anna, Yamada, Kyosuke, Auersperg, Nelly, Jinsong Liu, Lu, Karen H., Fishman, David, Gray, Joe W., Mills, Gordon B.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Diagnosis, Breast cancer

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Subjects list: Research, United States, Ovarian cancer, Guanosine triphosphatase, GTPases
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