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IL-15 and IL-2: a matter of life and death for T cells 'in vivo'

Article Abstract:

Research presented concerns the role of interleukin (IL)-2 and IL-15 in regulating T-cell proliferation and homeostasis 'in vivo.' Topics addressed include the regulation of cell divison, gene expression and receptor signaling.

Author: Xian Chang Li, Demirci, Gulcin, Ferrari-Lacraz, Sylvie, Groves, Chris, Coyle, Anthony, Malek, Thomas R., Strom, Terry B.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Statistical Data Included, Cellular control mechanisms, Cell regulation, Interleukin-2, Homeostasis

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Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

Article Abstract:

An experiment carried out on animals suffering from multiple sclerosis is described. A myelin oligodendrocyte glycoprotein is developed.

Author: Strom, Terry B., Wucherpfennig, Kai W., Sobel, Raymond A., Kuchroo, Vijay K., Awasthi, Amit, Bettelli, Estelle, Gao, Wenda, Korn, Thomas, Oukka, Mohamed, Petersen, Troels R., Reddy, Jayagopala, Backstrom, Thomas B.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
Science & research, Care and treatment, Causes of, Risk factors, Multiple sclerosis, Myelin proteins

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Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

Article Abstract:

Immune tolerance cannot be induced in mice with defective T-cell apoptosis. This shows that deletion of alloreactive T cells is necessary for inducing tolerance to a transplant.

Author: Strom, Terry B., Zheng, Xin Xiao, Turka, Laurence A., Wu, Zihao, Hancock, Wayne W., Nunez, Gabriel, Wells, Andrew D., Li, Yongsheng, Li, Xian Chang, Walsh, Matthew C., Tang. Aimin, Sayegh, Mohamed
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Cell death, Immunological tolerance, Immunologic tolerance

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Subjects list: Research, United States, T cells
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