Helping the heart to heal with stem cells

Article Abstract:

Research discussed concerns the use of bone marrow-derived angioblasts to encourage cardiac revascularization in the aftermath of a myocardial infarction or heart attack. Topics addressed include the physiological aspects of the myocardium and the utilization of stem cells to help the heart heal after a myocardial infarction.

Physiological aspects, Myocardial revascularization, Heart muscle, Myocardium

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Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function

Article Abstract:

Research presented concerns the left-ventricle remodeling process after myocardial infarction, focusing on ways to inhibit myocardial remodeling and regenerate cardiac myocytes using mesenchymal stem cells derived from bone marrow. The therapeutic use of cytokine-mobilized angioblasts for revascularization of the heart muscle is addressed.

Neovascularization

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Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy

Article Abstract:

The role of proliferator-activated receptor-delta (PPAR-delta) in the heart in vivo is studied with the help of a cre-loxP-mediated cardiomyocyte-restricted gene targeting approach by crossing mice carrying a loxP-flanked allele of Ppard, the gene that encodes PPAR-delta with cardiomyocyte-restricted Cre-expressing (alpha-MyHc-Cre) mice. The findings indicate that PPAR-delta is essential for maintaining basal cardiac function, possibly through maintenance of basal myocardial fatty acid oxidation.

Science & research, Causes of, Heart diseases, Cardiomyopathy, Myocardial diseases, Biological oxidation (Metabolism)

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