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Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

Article Abstract:

The safety and metabolic effects of high-dose immunosuppression were determined, followed by autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) in newly diagnosed type 1 diabetes mellitus (DM). With AHST, beta cell function was found to be increased in all but 1 patient and induced prolonged insulin independence in the majority of the patients.

Author: Burt, Richard K., Voltarelli, Julio C., Couri, Carlos E.B., Stracieri, Ana B.P.L., Oliveira, Maria C., Moraes, Daniela A., Pieroni, Fabiano, Coutinho, Marina, Malmegrim, Kelen C.R., Foss-Freitas, Maria C., Simoes, Belinda P., Foss, Milton C., Squiers, Elizabeth
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
Health aspects, Diagnosis, Drug therapy, Type 1 diabetes, Hematopoietic stem cells, Hematopoietic stem cell transplantation

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Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases

Article Abstract:

A study to ascertain the nonmalignant, nonhematologic clinical indications that could call for the use of blood-and bone marrow-derived stem cells is conducted. Results reveal that the use of stem cells ameliorated conditions in some autoimmune and cardiovascular diseases but called for further trials.

Author: Burt, Richard K., Pearce, William, Barr, Walter G., Beohar, Nirat, Loh, Yvonne, Craig, Robert, Yanting Wen, Rapp, Jonathan A., Kessler, John
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2008
Care and treatment, Cardiovascular diseases, Autoimmune diseases, Stem cells, Stem cell transplantation

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Subjects list: United States, Patient outcomes, Clinical report
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