Nucleotide polymorphism leads to reduced plasma factor levels

Article Abstract:

Japanese researchers have found a common polymorphism that causes the differences in the standard values of plasma levels of factor XII between Asians and Caucasians. They have found a high level of prevalence of 46 C to T substitution in Asians. This causes reduced levels of plasma FXII through low translation efficiency in hepatocytes among Asians. While the 46T polymorphism was identified in 73% of Asians, the 46C was found in 80% of Caucasians.

Genetic polymorphisms

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Quantity of latent virus correlates with reactivation

Article Abstract:

The reactivation rate and the site specificity of herpes simplex virus types 1(HSV-1) and HSV-2 are influenced by the amount of latent virus DNA. The latent amounts of HSV-1 and HSV-2 in the lumbosacral regions differ and so did the occurrence and frequency of infections. The anatomical regions affected by the two types also differ. While HSV-1 affects the oral-labial region, HSV-2 is more common in the genital region.

Herpes simplex virus

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Novel mutation site may affect hemostasis

Article Abstract:

A previously unidentified mutation of the factor V gene at exon 7 has been found among Hong Kong Chinese. Factor V is a cofactor in the transformation of prothrombin to thrombin in the coagulation process which is related to the maintenance of hemostasis. Previously, G1691 to A mutation has been the only genetic abnormality found for the human factor V gene resulting in activated protein C resistance.

Health aspects, Gene mutations, Gene mutation, Hong Kong, Hemostasis

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