Screening for Down syndrome using first-trimester combined screening followed by second-trimester ultrasound examination in an unselected population

Article Abstract:

A multicenter, interventional study is carried out to assess the performance, acceptability and cost-effectiveness of a pragmatic approach to Down syndrome screening, based on first-trimester combined screening, followed by routine trimester ultrasound examination in the unselected population of a single health authority. The results have shown that 1 pragmatic interventional 2-step approach using first-trimester combined screening followed by second-trimester detailed ultrasound examination is a suitable and acceptable option for Down syndrome screening in pregnancy.

Care and treatment, Risk factors, Medical screening, Health screening

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First-trimester nuchal translucency, nasal bones, and trisomy 21 in selected and unselected populations

Article Abstract:

A study was conducted to assess the role of fetal nasal bones evaluation in first-trimester screening for trisomy 21 in selected and unselected pregnancies by visualizing the nasal bones in women attending for routine nuchal translucency screening as well as in high-risk pregnancies referred to tertiary care center. The result showed that first-trimester nasal bones assessment for trisomy 21 screening has a very different performance in selected and unselected pregnancies.

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Fetal cardiac defects and increased nuchal translucency thickness: A prospective study

Article Abstract:

An association between increased nuchal translucency thickness and major cardiac defects in chromosomally normal fetuses is examined. As the incidence of cardiac defects in this population was high, fetal echocardiography was found.

Birth defects, Heart, Cardiovascular abnormalities, Echocardiography

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