Screening of HIV-1 isolates by reverse heteroduplex mobility assay and identification of non-B subtypes in Italy

Article Abstract:

The possible emergence in Italy of a new epidemic wave of HIV-1 non-B subtypes as well as recombinant forms, is suggested by the increasing prevalence of HIV-1 transmission through heterosexual contacts and the growing number of immigrants from non-western countries, where non-B subtypes and recombinant forms are prevalent. A modified heteroduplex mobility assay (HMA) strategy, reverse HMA (rHMA), is developed which allows rapid identification of divergent-from-B-subtype isolates.

Italy, Prevention, Medical examination, Communicable diseases, HIV patients, Disease transmission

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Effects of highly active antiretroviral therapy and immune recovery on CD[8.sup.+] T-cell-mediated inhibition of HIV-1 transcription

Article Abstract:

A transient transfection assay and a reporter gene activated by the HIV-1 long terminal repeat (LTR) was used to analyze CD[8.sup.+] antiviral factor (CAF) production in CD[8.sup.plus] T cells of HIV-1 positive individuals. The results suggest that immune recovery after highly active antiretroviral therapy (HAART) contributes to the normalization of CAF levels in HIV-1 positive individuals.

Science & research, Health aspects, Research, Complications and side effects, Risk factors, Highly active antiretroviral therapy, CD8 lymphocytes, Ir genes, Clinical report

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