Silencing mutant SOD1 using RNAi protects against neurodegenration and extends survival in an ALS model

Article Abstract:

A lentiviral vector to mediate expression of RNAi molecules specifically targeting the human superoxide dismutase (SOD1) gene is generated. Equine infectious anemia virus (EIAV) mediated silencing of mutant SOD1 expression in vulnerable motor neuron populations using shRNA causes long-term reversal of a dominantly inherited form of amyotrphic lateral sclerosis (ALS) in a transgenic mouse model.

Genetic aspects, RNA, Superoxide dismutase

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Putting the heat on ALS

Article Abstract:

Investigations have shown that daily treatments with arimoclomol, a coinducer of heat shock proteins alleviate symptoms of neurodegeneration and prolongs lifespan in a mouse model of amyotrophic lateral sclerosis (ALS). This is true even administered after onset, providing a new therapeutic approach to this disease.

Nervous system, Neurodegenerative diseases

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Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

Article Abstract:

Arimoclomol, a coinducer of heat shock proteins (HSPs) prevents the progressive loss of motoneurons and muscle function in an amyotrophic lateral sclerosis (ALS) mice model. Pharmacological activation of heat shock response is found to be a successful therapeutic approach to neurodegenerative diseases like (ALS).

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