Spanish HIV-1-infected long-term nonprogressors of more than 15 years have an increased frequency of the CX3CR1 249I variant allele

Article Abstract:

A study was conducted to determine whether functionally active CX3CR1 genetic variants are associated with long-term nonprogressive (LTNP) infection of less than 15 years in HIV-1 infected Spanish patients. The result shows that CX3CR1 249I variant allele is more frequent in Spanish HIV-1 infected LTNPs of less than 15 years, and the effect is independent of the presence of the CCR5(delta)32 allele.

Allelomorphism, Alleles, Genetic research

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Effect of genetic variants of CCR2 and CCL2 on the natural history of HIV-1 infection: CCL2-2518GG is overrepresented in a Cohort of Spanish HIV-1-infected subjects

Article Abstract:

A study was carried out to determine whether functionally active CCR2 and CCL2 genetic variants influence the risk of infection and disease progression in a cohort of white Spaniards. The distribution of CCL2 alleles showed no significant differences between groups but HIV-1-infected individuals had a significantly higher prevalence of the variant homozygous CCL2 GG genotype as compared to EUs.

Analysis, Risk factors, Genetic aspects, Natural history, Clinical report

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Lack of association of SDF-1 3'A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years

Article Abstract:

The frequency of the SDF-1 3'A allelic variant in a cohort of white Spaniards made up of Human Immunodeficiency Virus (HIV)-1-infected long-term nonprogressors (LTNPs) older than 16 years of age, HIV-1-infected usual progressors and a group of healthy controls are studied. The results indicate that the SDF-1 3' A polymorphism is not a determinant of LTNP in HIV-1-infected Spanish patients.

United States, Health aspects, Development and progression, Spaniards

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