The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis

Article Abstract:

A study demonstrates that Ptpn6(super me-v/me-v) mice bearing a functionally deficient SHP-1 protein are markedly glucose tolerant and insulin sensitive as compared to wild-type littermates, as a result of enhanced insulin receptor signaling to IRS-PI3K-Akt in liver and muscle. Tyrosine phosphorylation of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) and clearance of serum [(super 125)I]-insulin were markedly increased in SHP-1-deficient mice or SHP-1-deficient hepatic cells in vitro, indicating a crucial role for SHP-1 in negatively modulating insulin action and clearance in the liver, thereby regulating whole-body glucose homeostasis.

United States, Protein tyrosine kinase, Protein-tyrosine kinase, Glucose intolerance

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Dual role of proapoptotic BAD in insulin secretion and beta cell survival

Article Abstract:

The dual physiologic significance of the proapoptotic BCL-2 family member BAD in glucose-stimulated insulin secretion and beta cell survival is discussed. BAD is found to majorly help in the survival of the beta cell by regulating the physiologic adaptation of the beta cell mass during high-fat feeding.

Genetic aspects, B cells, Insulin, Glucose, Chemical properties, Dextrose, Apoptosis

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Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

Article Abstract:

Research has been conducted on the inducible nitric oxide synthase, induced by the inflammatory cytokines in skeletal muscle and fat. The effect of the chronic inducible nitric oxide synthase on the muscle insulin resistance has been investigated and the results are discussed.

Canada, Statistical Data Included, Analysis, Causes of, Physiological aspects, Obesity, Medical research, Muscles, Nitric oxide, Insulin resistance

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