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Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant

Article Abstract:

A vaccine against Lyme disease appears to be effective in a high-risk area. Researchers gave a placebo or a vaccine made from the outer-surface lipoprotein A of the organism that causes Lyme disease to 10,936 people who lived in areas where Lyme disease is endemic. After three doses, the vaccine reduced the infection rate by 76%. Administration of the vaccine caused mild-to moderate side effects.

Author: Sikand, Vijay K., Nowakowski, John, Schmid, Christopher H., Steere, Allen C., Fikrig, Erol, Krause, David S., Schoen, Robert T., Meurice, Francois, Parenti, Dennis L., Laukamp, Sabine, Buscarino, Charles
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
Evaluation, Prevention, Bacterial vaccines

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Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease

Article Abstract:

Prolonged antibiotic treatment does not appear to help patients with Lyme disease who do not respond to the initial antibiotic treatment. This was the conclusion of a study of 129 patients who were treated for up to 90 days with oral and intravenous antibiotics.

Author: Klempner, Mark S., Hu, Linden T., Evans, Janine, Schmid, Christopher H., Johnson, Gary M., Trevino, Richard P., Norton, DeLona, Levy, Lois, Wall, Diane, McCall, John, Kosinski, Mark, Weinstein, Arthur
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
Drug therapy

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Taking a bite out of vector-transmitted infectious diseases

Article Abstract:

The article views alternative methods to arrest and control the spread of different vector borne diseases in endemic areas.

Author: Unnasch, Thomas R., Klempner, Mark S., Hu, Linden T.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
United States, Methods, Control, Vector control, Vector-borne diseases

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Subjects list: Lyme disease
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