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Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia

Article Abstract:

Anti-HIV drugs can still be useful even if the virus develops resistance to them. This was the conclusion of a study of 16 HIV patients, somie of whom discontinued the drugs. Although the virus became susceptible to the drugs again when the drugs were discontinued, CD4 T cell counts decreased and viral levels increased.

Author: Petropoulos, Christos J., Deeks, Steven G., Wrin, Terri, Liegler, Teri, Hoh, Rebecca, Hayden, Matthew, Barbour, Jason D., Hellmann, Nicholas S., McCune, Joseph M., Hellerstein, Marc K., Grant, Robert M.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
Health aspects, Drug therapy, Anti-HIV agents

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Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis

Article Abstract:

Research presented concerns the relationship between HIV-1-mediated T-cell loss and lymphocyte development or increased thymic function. Findings suggest that a homeostatic response to T-cell loss is an increase in the production of interleukin-7.

Author: Andersson, Jan, Deeks, Steven G., McCune, Joseph M., Grant, Robert M., Napolitano, Laura A., Schmidt, Diane, De Rosa, Stephen C., Herzenberg, Leonore A., Herndier, Brian G.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Research, Interleukins, Cellular control mechanisms, Cell regulation, T cells, Immunohistochemistry

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Impaired replication of protease inhibitor-resistant HIV-1 in human thymus

Article Abstract:

Research has been conducted on the recombinant HIV-1 clones that contain wild-type or the protease inhibitor-resistant protease domains. The study of these clones in the activated peripheral blood mononuclear cells and in human thymic organ cultures has been carried out and the results indicate that the wild-type and protease inhibitor-resistant HIV-1 isolates have replicated in peripheral blood mononuclear cells.

Author: Deeks, Steven G., McCune, Joseph M., Grant, Robert M., Stoddart, Cheryl A., Liegler, Teri J., Mammano, Fabrizio, Linquist-Stepps, Valerie D., Hayden, Matthew S., Clavel, Francoise
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
France, Analysis, Causes of, Physiological aspects, Genetic aspects, Medical research, Proteases, Cloning, Thymus, Thymus gland, Blood cells

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Subjects list: HIV infection, HIV infections, Statistical Data Included, United States
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