Foundations of Pharmacology

Article Abstract:

'Foundations of Pharmacology', available in book and disk formats, provides an overview of statistical methods and data analysis. It also discusses theories of drug action and analyzes key concepts of pharmacokinetics. The disk contains several useful programs which complements the book. The text is concise, clear, authoritative and thought-provoking. However, there is absence of clear learning objective, summaries, numerical problems and definition of terms. Despite its shortcomings the package is of value to postgraduate students and scientists.

Evaluation, Product/Service Evaluation, Medical Review System (Medical/health software)

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Structural basis of voltage-gated K+ channel pharmacology

Article Abstract:

Pharmacological and electrophysiological experiments in recombinant DNA techniques have significantly improved our understanding of the structure of voltage-gated K+ channels and their impact on drug administration. Certain diseases such as cardiac arrhythmias, hypertension and smooth muscle disorders, can be treated by drugs that alter various K+ channels. Pharmacologists need to develop K+ channel blockers that are directed away from the external pore regions of the channel

Usage, Pharmacology, Experimental, Pharmacological research

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Pharmacology and electrophysiology of ATP-activated ion channels

Article Abstract:

The pharmacological and electrophysiological properties of adenosine triphosphate-channels were studied and results show that these channels are ligand-gated and are present in muscle and neural cells. The receptor on the ATP-activated ion channel is of the P2 type with reactive blue 2 dye as a potent competitive antagonist. However, data on potential channel blockers are limited. It is suggested that these channels have a nicotinic acetylcholine-like receptive subunit.

Physiological aspects, Electric properties, Cells (Biology), Cells, Adenosine triphosphate, ATP, Ion channels, Electrophysiology

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