K+ channel openers and 'natural' cardiac protectors

Article Abstract:

K+ channel openers can be used to prevent angina because of their ability to promote vascular smooth muscle relaxation. This cardioprotective effect is due to the opening of plasmalemma K+ channels, specifically those mediated by intracellular adenosine triphosphate (ATP) levels. Adequate cardiac perfusion is provided to prevent the post-ischemic effects such as the accumulation of anaerobic metabolites and depleting ATP stores. It serves to precondition the heart against ischemia by hastening the loss of contractile activity in the compromised zone through the shortening of myocardial action potentials.

Care and treatment, Drug therapy, Coronary heart disease, Vascular smooth muscle, Angina pectoris

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P/Q-type Ca2+ channel defects in migraine, ataxia and epilepsy

Article Abstract:

Calcium channels and mutations observed in the Ca2+ channel alpha1A-subunit gene in human and mouse inherited channelopathies are investigated to gain better understanding on migraine and other cerebral disorders. Results showed similarities between humans and mice. Mutant mice were observed for ataxic behavior expressed through splayed stance and hopping gait. The behavior and progressive cerebellar atrophy in the mutant mice were found to be similar to symptoms described in individuals with familial hemiplegic migraine, episodic ataxia type 2 and cerebellar ataxia.

Cerebellar ataxia, Gene mutations, Gene mutation, Genetic aspects, Calcium channels, Brain diseases, Migraine

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Maximal function of minimal K(sup)+ channel subunits

Article Abstract:

This article discusses the structural and functional aspects of KCNE proteins involved in the biological transport of potassium ions. Results suggest that KCNE proteins are beta-subunits, consist of 103-153 amino acids, and influence gating of potassium channels.

United States, Analysis, Brief Article, Physiological aspects, Biological transport, Active, Active biological transport, Secretion, Physiological regulation, Structure-activity relationships (Biochemistry)

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