Use of the elevated plus maze in the search for novel anxiolytic agents

Article Abstract:

Research on new anxiolytic agents and the psychological and neurochemical bases of anxiety has made extensive use of the rodent model of anxiety known as the elevated plus maze test. The test's popularity can be attributed to its speed and simplicity, its cheap equipment and its ability to detect putative anxiolytics such as CCKB receptor antagonists. However, the test's proneness' for false positives and false negatives makes it unsuitable for anxiolytic and anxiety research.

Models, Usage, Tranquilizing drugs, Tranquilizing agents, Mandatory drug testing, Drug testing, Anxiety

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Two novel families of ectonucleotidases: molecular structures, catalytic properties and a search for function

Article Abstract:

The E-NTPase and PDNPase are two novel and unrelated ectonucleotidase families that have wide substrate specificity, as well as tissue and cell distribution. Members of the E-NTPase family hydrolyse either nucleoside 5'-triphosphates or both diphosphates and nucleoside 5'-triphosphates. Members of the PDNPase family, on the other hand, hydrolyse pyrophosphate bonds of nucleotides and nucleotide sugars and phosphodiester bonds of nucleotides and nucleic acids.

Analysis, Nucleotide sequence, Base sequence, Nucleotides

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Beta-secretase revealed: starting gate for race to novel therapies for Alzheimer's disease

Article Abstract:

Four teams of researchers have independently succeeded in isolating beta-secretase. This enzyme breaks down the amyloid precursor protein to form beta-amyloid. Beta amyloid can accumulate in the brain, damaging brain cells and possibly causing Alzheimer's dementia.

Alzheimer's disease, Proteases, Identification and classification, Amyloid beta-protein

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