A pore way to die

Article Abstract:

Cells die by an uncontrolled energy-independent process called necrosis that involves the opening of a pore in the inner mitochondrial membrane, known as the mitochondrial membrane permeability transition pore. The hypothesis show that the pore has three components, found in the inner of the two mitochondrial membranes, which normally, transports ATP out of the mitochondria, the voltage-dependent anion transporter in the outer mitochondrial membrane, and cyclophilin D.

Cells, Cell permeability, Necrosis

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Article Abstract:

Mitochondria are found to be key regulators of cell survival and death and they have a central role in ageing. They are also found to interact with many of the specific proteins implicated in genetic forms of neurodegenerative diseases. It is believed that therapies targeting basic mitochondrial processes such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise.

New York, Analysis, Causes of, Gene mutations, Gene mutation, Nervous system, Oxidative stress, Neurodegenerative diseases

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