Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1

Article Abstract:

Phenotypes linked to a single point mutation in Notch1, Val1,744-Gly, are shown to resemble null Notch1 phenotype.

Phenotype, Phenotypes, Lethal mutation

---

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Article Abstract:

Two models are introduced to describe alternative mechanisms of notch protein interaction. The first supposes that the CBF1, Su(H), Lag-1 (Super 1-4), or CLS, interacts directly with the Notch protein to produce an intracellular signal. The second assumes that the Notch interacts indirectly with CSL via the Notch intracellular domain NICD.

Genetic aspects, Molecular biology, Cell research, Cytological research

---

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Article Abstract:

Efficient processing of the receptor protein Notch-1 to produce Notch intracellular domain (NICD) needs presenilin-1 (PS1) and is inhibited by gamma-secretase inhibitors. PS1 deficiency does not have an impact on the expression of endogenous Notch-1, its maturation by a furin-like enzyme and the translocation of NICD to the nucleus. The role of PS1 in Notch/beta-amyloid precursor protein (APP) processing could be that of a facilitator, directly exposing APP and Notch-1 to the gamma-secretase.

Proteases

Similar abstracts:

• Abstracts: Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein
• Abstracts: An experimental investigation into status-dependent male dimorphism in the European earwig, Forficula auricularia
• Abstracts: Queens, not workers, produce the males in the stingless bee Schwarziana quadripunctata quadripunctata. The role of queens in colonies of the swarm-founding wasp Parachartergus colobopterus
• Abstracts: ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
• Abstracts: Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.