Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice
Article Abstract:
Kainate receptors assembled with the GluR6 subunit are significant for both the sensitivity of CA3 neurons to kainate and for synaptic transmission at the mossy fibre-CA3 synapse, according to research using mutant mice lacking the kainate-receptor subunit GluR6. It was established that GluR6-deficient mice are less susceptible to systemic administration of kainate. This research indicates a vital role for kainate receptors, rather than alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors, in kainate-induced seizures and excitoxic neuronal death in the hippocampus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
Article Abstract:
Cultured adult rat hippocampal progenitors (AHPs) were grafted to homotypic and heterotypic neurogenic sites and heterotypic non-neurogenic sites to analyze adult neurogenesis. Results showed that AHPs grafted to neurogenic sites were able to show neuronal differentiation. Moreover, AHPs grafted in the rostral migratory pathway were able to move into the olfactory bulb and differentiate themselves.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Regenerating the damaged central nervous system
Article Abstract:
Research on regeneration of damaged mammalian brains following injury is examined in detail.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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