An epithelial serine protease activates the amiloride-sensitive sodium channel
Article Abstract:
The activity of the epithelial sodium channel (ENaC) is important in the regulation of blood pressure and sodium balance. An analysis of the effects of the serine protease trypsin on ENaC activity in a Xenopus kidney epithelial cell line (A6) shows that exposure of the apical membrane to aprotinin results in a reduction in transepithelial sodium transport, which can be restored by exposure to trypsin. The functional properties of the new channel-activating protease 1, which is a member of the serine-protease family and which is involved in the regulation of ENaC activity, are presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel
Article Abstract:
It has been possible to prove the existence of the electroneutral Na+/HCO3 cotransporter, which is vital in regulating pHi in myocardial cells and in smooth-muscle cells from rat mesenteric artery and guinea-pig ureter. NBCn1 may play a role in the background Na+ conductance in these tissues.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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The voltage-sensitive sodium channel is a bell-shaped molecular with several cavities
Article Abstract:
Research is presented describing the three-dimensional structure of the sodium channel membrane and the use such a model could have in the pharmaceutical industry.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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