RGS8 accelerates G-protein-mediated modulation of K+ currents

Article Abstract:

Research demonstrates that the RGS8 neural-tissue-specific RGS protein accelerates G-protein-coupled channel modulation and does not solely act as a negative regulator. RGS8 acts as a GTPase-activating protein and prefers to bind to the alpha-subunits G-alpha-i3 and G-alpha-o. RGS8 accelerated the turning on and off of the G-protein-coupled inwardly rectifying K+ channel (GIRK1/2) current following receptor stimulation when co-expressed with the GIRK1/2 and a G-protein-coupled receptor in Xenopus oocytes, while the dose-response relationship remained unaffected.

G proteins

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Aid from hair force

Article Abstract:

Tiny amplifiers in the inner ear of the mammals help them to hear with exquisite sensitivity and precision over a huge range of frequencies. However, provocative evidence has been provided that the main component of elusive 'cochlear amplifier' may reside in the hair bundles of the outer hair cells.

United States, Science & research, Usage, Hearing aids

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Tuning in with motor proteins

Article Abstract:

The inner ear's sensitivity relies on the amplification of vibration by a molecular motor in the organs of the Corti. The isolation of cDNA clones encoding the outer cell motor protein, prestin, is reported.

Anatomy, Ear

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