Analgesic effects of myrrh
Article Abstract:
Myrrh, a compound from shrubs of the genus Commiphora of the Burseraceae has two sesquiterpenes that produce analgesic effects. Naloxone inhibits the analgesic activity of myrrh, suggesting an interaction with brain opioid mechanisms. Furanoeudesma-1,3-diene, the major component of myrrh binds to opioid receptors in the membranes of the brain. The presence of other compounds in myrrh, whose effects have been unfavorable, probably caused the stoppage of the myrrh's use as a pain killer in favor of opioids.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Article Abstract:
Recent research has investigated the role of the mitochondrial uncoupling protein (UCP) in the regulation of body mass. It was found that mice which are deficient in UCP consume less oxygen after treatment with a beta3-adrenergic-receptor agonist. They seem to develop problems with thermo-regulation. It is possible that the loss of UCP is balanced out by UCP2, a homologue of UCP. Mice which are deficient in UCP may provide valuable information for the study of links between energy balance and obesity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Rewarding effects of opiates are absent in mice lacking the receptor for substance P
Article Abstract:
Research into the substance P receptor and the loss of the rewarding effects of opiates in mice lacking the receptor is presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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