BMP-4-responsive regulation of dorsal-ventral patterning by the homeobox protein Mix.1

Article Abstract:

A paired class homeobox protein, Mix.1, mediates the bone morphogenetic protein-4 (BMP-4) signalling pathway to dorsal-ventral patterning in Xenopus embryos. Mix.1 messenger RNA causes extensive blood formation in the embryo and alters dorsal mesoderm into a ventral one. Mix.1 expression is activated by BMP-4. Mix.1 forms heterodimers with the dorsalizing gene, siamois, which encodes a homeodomain protein. This protein is structurally similar to Mix.1. Mix.1 obstructs the duplicated axis activated by ectopic siamois expression.

Analysis, Gene expression, Xenopus

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Arkadia enhances nodal-related signalling to induce mesendoderm

Article Abstract:

Research is presented concerning the regulation of the induction of endoderm, mesoderm and mesendoderm tissue by the transforming growth factor beta family members which are nodal-related.

Growth, Cell nuclei, Cell nucleus

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Induction of the mammalian node requires Arkadia function in the extraembryonic lineages

Article Abstract:

Research is presented concerning the use of the retroviral ROSA betageo gene-trap vector for the production of recessive lethal gene-trap insertion mutations in the stem cells of embryos.

Research, Growth factors, Developmental biology

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