Bcl-2 promotes regeneration of severed axons in mammalian CNS

Article Abstract:

The neurons of the central nervous system of mammals usually lose their regenerative ability after a certain point in their development. Unlike retinal ganglion cells (RGCs) of embryos, RGCs from older animals cannot grow axons into tectum of any age. The role of the proto-oncogene bcl-2 in this developmental shift is examined. It is found to stimulate the growth and regenerate retinal axons, although this effect does not appear to be indirectly related to the proto-oncogene's anti-apoptotic activity.

Growth, Central nervous system, Axons, Neurons, Proto-oncogenes, Regeneration (Biology)

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Prions prevent neuronal cell-line death

Article Abstract:

Prion diseases are neurodegenerative conditions distinguished by an accumulation of a host-encoded glycoprotein, PrPSc. The normal cellular isoform, PrPC has an unknown physiological function although it may be involved in survival of Purkinje cells. Serum removal from the cell cultures was found to cause apoptosis in Prnp-1- cells but not in Prnp+/+ wild type cells.

Cell death, Prions, Prions (Proteins)

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Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex

Article Abstract:

Research is presented into the effects of disruption of N-methyl-D-aspartate receptors in the barrel cortex of rodents.

Cases, Brain research, Neurology, Neural transmission, Synaptic transmission

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