Cloning of inv, a gene that controls left/right asymmetry and kidney development

Article Abstract:

The majority of vertebrate internal organs exhibit a distinctive left/right asymmetry. The inversion of embryonic turning (inv) mutation in mice was previously created through random insertional mutagenesis, producing both a constant reversal of left/right polarity and kidney cyst formation. A new gene has been identified sited at the inv locus, containing 15 consecutive repeats of Ank/Swi6 motif. High expression is seen in the kidneys and liver in adult tissues. The candidate gene is the only one disrupted in inv mutants.

Abnormalities, Kidneys, Proteins, Kidney

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Evidence that mechanisms of fin development evolved in the midline of early vertebrates

Article Abstract:

The embryonic origin of catshark and lamprey median fins is examined to confirm whether median fin development involves the same genetic programs that function in paired appendages. The conservation of patterns of Hox and Thx gene expression suggests that the molecular mechanisms for fin development originated in the somitic mesoderm or midline of early vertebrates, and recurrence of these mechanisms in lateral plate mesoderm resulted in the origin of paired appendages.

Gene expression, Fins, Fins (Anatomy)

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Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch

Article Abstract:

The haemodynamics of ablation of unilateral Pitx2 expression in mice which impairs asymmetric remodelling of the branchial arch artery (BAA) system leading to randomized laterality of the aortic arch is described.

United Kingdom, Analysis, In situ hybridization, Hemodynamics, Laterality, Aorta, Thoracic, Thoracic aorta, Left and right (Psychology)

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