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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

An ARC/mediator subunit required for SREBP control of cholesterol and lipid homeostasis

Article Abstract:

A demonstration that the sterol regulatory element binding proteins (SREBPs) use the evolutionarily conserved ARC105 (also called MED15) subunit to activate target genes is presented and the structural analysis has revealed a three-helix bundle with marked similarity to the CREB-binding protein (CBP)/p300 KIX domain. The analysis has shown that the ARC105 is a key effector of SREBP-dependent gene regulation and control of lipid homeostasis in metazoans.

Author: Tjian, Robert, Wagner, Gerhard, Watts, Jennifer L., Naar, Anders M., Fajun Yang, Vought, Bryan W., Satterlee, John S., Walker, Amy K., Z.-Y. Jim Sun, DeBeaumont, Rosalie, Saito, R. Mako, Hyberts, Sven G., Shaosong Yang, Macol, Christine, Iyer, Lakshmanan, Van den Heuvel, Sander, Hart, Anne C.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Health aspects, Cholesterol, Homeostasis, Binding proteins

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Transcription regulation and animal diversity

Article Abstract:

This review discusses the genetic basis of evolutionary diversity within the context of existing whole-genome sequences. Comparative genome analyses point out that vertebrate genomes have about twice the number of genes than those of invertebrates. The increase in vertebrates is due to the duplication of existing genes and that organismal complexity occurs due to elaboration of gene transcriptional regulation.

Author: Tjian, Robert, Levine, Michael
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
United Kingdom, Analysis, Genetic aspects, Comparative analysis, Vertebrates, Evolution (Biology), Genetic regulation, Genomes, Evolution, Genes

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Composite co-activator ARC mediates chromatin-directed transcriptional activation

Article Abstract:

The activator-recruited cofactor (ARC) is shown to interact directly with several different activators, including SREBP-1a, VP16 and the p65 subunit of NF-KB. The ARC complex comprises 16 or more subunits, some of which are novel gene products. It is likely to be identical to the nuclear hormone-receptor cofactor DRIP.

Author: Tjian, Robert, Naar, Anders M., Solomon, William, Beaurang, Pierre A., Zhou, sharleen, Abraham, Shaji
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
Research, Protein binding

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Subjects list: United States
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