Impaired Ptdlns (4,5) P (sub 2) synthesis in nerve terminals produces defects in synthetic vesicle trafficking

Article Abstract:

Phosphatidylinositol-4, 5-bisphosphate (PtdIns (4,5) P2) has an important function in cell regulation both as a precursor of second messenger molecules and by means of its direct interactions with cytosolic and membrane proteins. Biochemical studies have suggested a role for PtdIns (4,5) P2 in clathrin coat dynamics, and defects in its dephosphorylation at the synapse produce an accumulation of coated endocytic intermediates. Results demonstrate a critical role for PtdIns (4,5) P2 synthesis in the regulation of multiple steps of the synaptic vesicle cycle.

United States, Membrane proteins, Phosphatidylinositol, Phosphatidylinositols

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Synapse-specific control of synaptic efficacy at the terminals of a single neuron

Article Abstract:

Changes in the size of muscles during development are linked to the synaptic efficiency of motor neurons. One theory is that a signal from the muscle to the motor neuron maintains the link between the two. However, research has shown that there are two processes which control the effectiveness of single motor neurons. An increase in muscle innervation causes a reduction in presynaptic transmitter release and a reduction of muscle innervation causes an increase.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Scientific Research and Development Services, Neurological R&D, Research & Development-Universities, Motor neurons, Neurological research, Neurotransmitters, University research, Neural transmission regulation

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Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo

Article Abstract:

The role of Synaptotagmin I (Syt I) during endoctyosis in vivo is tested. Quantitative live imaging of a pH-sensitive green fluorescent protein fused to a synaptic vesicle protein (synapto-pHluorin) is used to measure the kinetics of endocytosis in sytI-null Drosophila.

Drosophila, Membrane fusion

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