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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA

Article Abstract:

Group-A Xeroderma pigmentosum (XPA)-deficient mice show high vulnerability to ultraviolet-B-induced and 7,12-dimethylbenz-(a) anthracene (DMBA)-induced skin and eye carcinogenesis. These results reveal that XPA-deficient mice are excellent mimics of the human Xeroderma pigmentosum phenotype. The potential of XPA-deficient mice for studying the high rates of skin cancers due to ultraviolet radiation and chemical carcinogens is discussed.

Author: Vries, Annemieke de, Oostorm, Conny Th. M. van, Hofhuis, Frans M.A., Dortant, Paul M., Berg, Rob J.W., Gruiji, Frank R. de, Wester, Piet W., Kreiji, Coen F. van, Capel, Peter J.A., Steeg, Harry van, Verbeek, Sjef J.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
Ultraviolet radiation, Carcinogens, Xeroderma pigmentosum

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Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

Article Abstract:

Research is presented concerning the influence of Saccharomyces cerevisiae kinases which are cyclin-dependent on the inhibition of DNA re-replication through several over-lapping mechanisms such as phosphorylation.

Author: Nguyen, Van Q., Co, Carl, Li, Joachim J.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Chromosome replication, Saccharomyces cerevisiae

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Direct observation of hole transfer through DNA by hopping between adenine bases and by tunnelling

Article Abstract:

Research is presented concerning the measurement of the efficiency of the transfer of charge between guanines which are separated by double stranded adenine-thymine bridges of varying lengths in the DNA molecule.

Author: Giese, Bernd, Amaudrut, Jerome, Kohler, Anne-Kathrin, Spormann, Martin, Wessely, Stephan
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Research, Biochemistry, Guanine

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Subjects list: Physiological aspects, DNA, Letter to the Editor
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