MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
Article Abstract:
The chemoattractant proteins (chemokines) monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) both trigger the firm adhesion of monocytes. However, there are differences in the contribution of specific integrin adhesion receptors to the induced adhesion for these two agonists. This is possibly because they use different signalling mechanisms. It has been established that IL-8 receptors on monocytes are functional. Specific chemokines are vital for monocyte recruitment.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Chitin induces accumulation in tissue of innate immune cells associated with allergy
Article Abstract:
Research has shown that chitin has induced the accumulation in tissue of interleukin (IL)-4-expressing innate immune cells, including eosinophils and basophiles, when given to mice. Chitin is found to be a recognition element for tissue infiltration by innate cells that are implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans
Article Abstract:
CD8+ lymphocytes are thought to be important in host defence against the human immunodeficiency virus (HIV-1). Mediators of viral inhibition were found to be localized in the cytolytic granules of HIV-1-specific CD8+ cytotoxic T lymphocytes (CTL). The mediators are secreted together, resulting in lysis of virion-producing cells and inhibition of free virus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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