Modification by nuclear export?

Article Abstract:

Research into the regulated nuclear export of NF-AT4, a transcription factor with both a nuclear-localization signal and a nuclear-export signal, indicates that the phosphatase calcineurin antagonizes the export receptor Crm1-mediated nuclear export of NF-AT4. Calcineurin was found to compete with Crm1 for binding to NF-AT4. It appears that Crm1-mediated export, and the competition between Crm1 and calcineurin, affect whether or not nuclear NF-AT4 is incorporated into a productive transcriptional complex.

Genetic transcription, Transcription (Genetics)

---

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

Article Abstract:

The three dimensional structure of the site where the nuclear factor of activated T-cells (NFAT) and AP-1 heterodimer (Fos-Jun) bind to DNA has been studied using crystallography, and shows a groove in the structure where 15 base pairs can be recognised. The overall complex shows tight binding but is likely to be a substructure of a larger structure, and could have additional components associated with it. The MOLSCRIPT program was used to generate the three dimensional representations.

Research and Development in the Physical, Engineering, and Life Sciences, Biological Product (except Diagnostic) Manufacturing, Drugs, Deoxyribonucleic Acid, Molecular Biology, DNA, Crystallography, DNA-ligand interactions, DNA binding

---

Similar abstracts:

• Abstracts: Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA. Crystal structure of the CorA M[g.sup.2+] transporter
• Abstracts: Caching decisions by grey squirrels: a test of the handling time and perishability hypotheses. The innate basis of food-hoarding decisions in grey squirrels: evidence for behavioural adaptations to the oaks
• Abstracts: Overlapping and matching in the song contests of black-capped chickadees. Aggressive responses of male and female rufous-and-white wrens to stereo duet playback
• Abstracts: A protein conjugation system essential for autophagy. The role of autophagy during the early neonatal starvation period
• Abstracts: L-type calcium channels and GSK-3 regulate the activity of NF-Atc4 in hippocampal neurons. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.