Role for c-Abl tyrosine kinase in growth arrest response to DNA damage

Article Abstract:

The c-Abl protein tyrosine kinase arrests cells in the G1 phase by a mechanism dependent on the p53 tumor suppressor protein in response to DNA damage. Both wild type and inactive c-Abl stimulate the activity of p53 and p21, a p53 effector, in MCF-7 cells exposed to ionizing irradiation. However, only wild-type c-Abl arrests growth by suppressing cyclin-dependent kinase 2 activity. The activity of p21 is unessential for growth arrest as c-Abl arrests growth in cells lacking p21 but not in those lacking p53. The kinase-defective c-Abl mutant stimulates p53 but is unable to arrest growth.

Physiological aspects, Cells (Biology), Growth, DNA damage, Cells, Protein tyrosine kinase, Protein-tyrosine kinase

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Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice

Article Abstract:

The myogenic transcription factor, Myf-5 protein, is essential for the cells' response to positional cues in the mice embryo and helps them adopt a myogenic fate. The targeting of the nlacZ reporter gene into the myf-5 locus demonstrates that beta-galactosidase muscle progenitor cells are present in the dermomyotome of myf-5 null embryos. These cells undergo a normal epithelial to mesenchymal transition, but migrate abnormally. The cells accumulates dorsally under the ectoderm, whereas ventrally they fail to localize correctly and are found in ribs.

Research, Analysis, Genetic transcription, Transcription (Genetics), Mice as laboratory animals, House mouse, Myogenesis

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