Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice

Article Abstract:

Homozygous mice in which the Hoxa10 of the Abdominal B gene is absent are viable. However, the males show bilateral cryptorchidism where the position and development of the testis is abnormal. Although only 40% of the homozygous male mice are sterile when young, the number of sterile males increases with age. The homozygous females show normal ovulation, but, due to death of the preimplantation embryos, almost 80% of the females are sterile. The reproductive tissues of these females did not show histological differences from the wild-type females.

Genetic aspects, Mice as laboratory animals, House mouse, Reproductive organs, Genitalia

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Classic clues to NSF function

Article Abstract:

Mutations in the N-ethylmaleimide-sensitive fusion protein (NSF) cause temperature-sensitive paralysis in comatose mutants of Drosophila. NSF acts at the yeast vacoular vesicles at a pre-docking stage. It helps in folding the Botulinum neurotoxin substrates into a manner adequate for vesicle docking and fusion. The NSF takes more time to act than the synaptic vesicle recycling.

Proteins

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