Sinful repression

Article Abstract:

A number of significant developments have been made recently in research into the molecular mechanisms which control the access of transcription factors and RNA polymerase to DNA. There is growing evidence that reversible alterations in histone chemistry have a significant controlling function. One research project shows that N-CoR, which is recognized as a co-repressor for the thyroid-hormone receptor, interacts in a complicated way with the mammalian homologues of RPD3 and Sin3, yeast co-repressors.

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Transcriptional squelching re-examined

Article Abstract:

Genetic research shows that gene squelching occurs only in the episomal target genes of mammalian cells. Genes integrated into cellular chromatin are not affected by the process. Experiments using chimaeric transcription factors and gene targets suggest that episomal gene transcription may be controlled by different limiting factors. Other physiological differences may exist to explain the processes involved.

Genetic engineering, Cytology, Mammals

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